Dietary Intake of Milk Thistle Seeds as a Source of Silymarin and Its Influence on the Lipid Parameters in Nonalcoholic Fatty Liver Disease Patients

Nonalcoholic fatty liver disease (NAFLD), which is associated with obesity, the most common reason for chronic hepatitis in developed countries. Its therapy includes a low-energy diet, physical activity and also various antioxidative compounds, such as milk thistle (Silybum Marianum) seeds, are natural source of silymarin. The aim study was to assess influence 3 months including dietary recommendations combined daily supply on biochemical parameters NAFLD patients. conducted group 20 patients (11 females, 9 males) excessive body mass diagnosed. For months, participants received doses 7.1 g silymarin (210 mg day). They were monitored every 2 weeks. Their composition assessed. It observed that studied did not follow their recommendations, when comparing baseline diet after there no differences (for vast majority nutrients; p < 0.05). Patients results those parameters; However, it indicated blood triglyceride levels (140.36 ± 14.92 vs. 110.04 37.23 mg/dL; = 0.0017) gamma-glutamyltransferase (GGT) decreased (23.03 12.87 12.77 5.24 U/L; 0.0008). As changed within period, may be supposed beneficial decrease GGT obtained due an everyday additional recommendation patients, allows one obtain effects, even if other followed.